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The personnel of Newcastle University and other institutions released in the latest issue of magazine Current Biology that in modern society, more and more women plan to give birth to children until about 40 years old so the resulted various fertility problems are continuously increasing. The study found that aged women were vulnerable to have problems of fertility might be associated with some protein.
The researchers did comparison and analysis of the experimental rat in different age of generating ova. The results showed that the function of a kind of vivo protein called cohesin aged while aging. The role of the protein is to connect the chromosomes together. There are usually two sets of chromosomes in somatic cells, but when the ova come into being, it requires the cohesion to accurately "cut" them in order to be a free set of chromosomes in germ cells. If the cohesin has dysfunction, that can lead to abnormal chromosome numbers in the ova wholesale air max plus for sale , then resulting in infertility, miscarriage or birth defects and other problems.
Dr. Mary Herbert who led the research team said the age rats used in experiments were equivalent to the human age of about 40 years old, whose cohesin’s function has been significantly reduced, often leading to abnormal chromosome numbers in the ova and the corresponding fertility problems. This showed that cohesin’s aging might be the underlying cause of 40-year-old women’s fertility decline by a big margin. The findings also help search for treatment.
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